Chemically Paracetamol is known as N-(4-hydroxyphenyl)ethanamideN-(4-hydroxyphenyl)acetamide (Acetaminophen)1which is a potent non-steroidal anti-inflammatory agent. Paracetamol is a widely use over the counter pain reliver and antipyretic drug. The present study describes a simple, sensitive and rapid colorimetric method for determination of paracetamol in bulk and tablet dosage form. The method is based on reaction of FC Reagent with phenolic compounds, which involves the oxidation of phenolic compounds by FC reagent in alkaline medium, producing a blue molybdo tungstate complex. The produced complex was measured using uv spectrophotometer at 648 nm. The developed method was validated in terms of precision, specificity, linearity and range. This method provides quick and cost effective quality control tool for routine analysis of paracetamol in bulk and tablet dosage form.
Loading....